N-Acetyl-9-azido-9-deoxy-neuraminic acid

CAS: 76487-51-9

Ref. 3D-MA30919

Produktinformation

• Name: N-Acetyl-9-azido-9-deoxy-neuraminic acid
• Synonyme: 5-(Acetylamino)-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-2-nonulosonic acid9-Azido-N-acetylneuraminic acid

Beschreibung

N-Acetyl-9-azido-9-deoxy-neuraminic acid is used as a sialic acid substitute for metabolic glycan labelling, which allows glycan-protein interactions and sialylations to be interrogated. Naturally occurring glycans can be di-sialylated by sialidase and replaced by a sialyl analogue, such as N-acetyl-9-azido-9-deoxy-neuraminic acid, using sialyltransferase. The modified glycans are then resistant to sialidase. Reduction of the azide functionality of N-acetyl-9-azido-9-deoxy-neuraminic acid affords access to an additional 9-amino sialic acid analogue which can be further elaborated to 9-amido analogues.

Glycans labelled with N-acetyl-9-azido-9-deoxy-neuraminic acid can be tagged and imaged by reaction of the 9-azido group with, for example, a fluorescent tag introduced via a Staudinger ligation.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 334.28 g/mol
• Formel: C₁₁H₁₈N₄O₈
• Reinheit: Min. 90 Area-%
• Farbe/Form: Off-White Powder