Isofagomine D-tartrate

CAS: 957230-65-8

Ref. 3D-MI24675

Produktinformation

• Name: Isofagomine D-tartrate
• Synonyme: (3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-dihydroxybutanedioateAfegostat

Beschreibung

Inhibitor of lysosomal acid β-glucosidase (GlcCerase/glucocerebrosidase) with IC50 in nanomolar range for wildtype and mutant enzyme. It behaves as pharmacological chaperon by binding to instable GlcCerase active site at neutral pH values and facilitating the protein folding. In acidic lysosomes, isofagomine gets release from the enzyme active site. This results in increased levels of functional glucocerebrosidase and brings therapeutic benefits to patients with Gaucher disease.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 297.26 g/mol
• Formel: C₁₀H₁₉NO₉
• Reinheit: Min. 95%
• Farbe/Form: White Powder