2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide

CAS: 7408-41-5

Ref. 3D-MT06420

Produktinformation

• Name: 2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide
• Synonyme: (2R,3R,4R,5R)-2-Azido-5-[(benzoyloxy)methyl]tetrahydrofuran-3,4-diyl dibenzoate (non-preferred name), (2R,3R,4R,5R)-2-azido-5-{[(phenylcarbonyl)oxy]methyl}tetrahydrofuran-3,4-diyl dibenzoate (non-preferred name), 2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl azide

Beschreibung

2,3,5-Tri-O-benzoyl-b-D-ribofuranosyl azide (2,3,5-TRBA) is an antiviral agent that inhibits the synthesis of viral nucleic acid by targeting a glycosylation step in the synthesis of herpes simplex virus type 1 (HSV1). 2,3,5-TRBA has significant antiviral activity against HSV1 and other herpes viruses. This compound is also active against influenza A virus and vaccinia virus. 2,3,5-TRBA inhibits the enzyme triosephosphate isomerase (TPI), which catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde 3-phosphate. Inhibition of TPI leads to decreased glucose production in cells infected with herpes viruses. The acetonitrile used as a solvent in this reaction can be replaced by pyridine or DMF. The sulfonate group

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 487.46 g/mol
• Formel: C₂₆H₂₁N₃O₇
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder