Tri-b-GalNAc-6-aminohexanoate

Ref. 3D-MT184237

Produktinformation

• Name: Tri-b-GalNAc-6-aminohexanoate
• Synonyme: Tris-GalNAc-(CH2)6-NH2Triantennary β-GalNAc 6-aminohexanoatetri-beta-GalNAc-6-ACATris-GalNAc-Ahx-NH2Tris-β-GalNAc-6-aminohexanoi c acid

Beschreibung

Tri-b-GalNAc-6-aminohexanoate is a synthetic ligand designed to target the asialoglycoprotein receptor (ASGPR) on hepatocytes. The three terminal beta-N-acetylgalactosamine (GalNAc) sugars provide an efficient ASGPR binding. It serves as a platform for lysosomal targeting chimera (LYTAC) development, allowing for the creation of chimeras that specifically target unwanted proteins for degradation within hepatocytes. In addition, tri-b-GalNAc-6-aminohexanoate facilitates the delivery of therapeutic cargo, such as RNA or Cas9 complexes, directly to hepatocytes via ASGPR-mediated endocytosis. This approach is promising for gene therapy and RNAi applications in the liver due to the specificity of ASGPR targeting and the versatility of the conjugation moiety.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,528.75 g/mol
• Formel: C₆₇H₁₂₁N₁₁O₂₈
• Reinheit: Min. 95%