8-Azidocyclic adenosine diphosphate ribose

CAS: 150424-94-5

Ref. 3D-NA06324

Produktinformation

• Name: 8-Azidocyclic adenosine diphosphate ribose
• Synonyme: 8-Azido-D-cyclic adenosine diphosphate ribose, (32P)8-Azido-cyclic ADP ribose, 8-Azido-N-alpha-D-ribofuranosylandenosine 5'-(trihydrogen diphosphate) intramol. P'-5''-ester, 8-Azido-cyclic ADP-ribose, 8-N3-Cadpr, Andenosine 5'-(trihydrogen diphosphate), 8-azido-N-alpha-D-ribofuranosyl-, intramol. P'-5''-ester, (24Z)-18-azido-24-imino-7,9,11,25,26-pentaoxa-1,17,19,22-tetraaza-8,10-diphosphapentacyclo[18.3.1.1~2,5~.1~13,16~.0~17,21~]hexacosa-18,20,22-triene-3,4,8,10,14,15-hexol 8,10-dioxide (non-preferred name)

Beschreibung

8-Azidocyclic adenosine diphosphate ribose (8AADPR) is a molecule that is synthesized from ATP and ribose. It has been shown to inhibit the endoplasmic reticulum Ca2+-ATPase, which transports calcium ions out of the cell, leading to increased concentrations of calcium ions in the cytosol. 8AADPR also inhibits mitochondrial ATPase, which leads to an accumulation of ADP-ribose within mitochondria. This accumulation leads to the inhibition of protein synthesis within mitochondria and an activation of ryanodine receptors. There are no known adverse effects associated with 8AADPR at this time, but it should be used with caution due to its potential effects on cardiac function.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 582.31 g/mol
• Formel: C₁₅H₂₀N₈O₁₃P₂
• Reinheit: Min. 95%