3'-O-Acetylthymidine

CAS: 21090-30-2

Ref. 3D-NA08376

Produktinformation

• Name: 3'-O-Acetylthymidine
• Synonyme: 3'-O-Acetyl-D-thymidine, 1-(3-O-acetyl-2-deoxypentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione

Beschreibung

3'-O-Acetylthymidine is a dinucleoside analogue of thymidine. It has been used as a model for human immunodeficiency virus (HIV) and has been shown to be resistant to HIV infection in vitro. 3'-O-Acetylthymidine inhibits the synthesis of protein by binding to the ribosomal RNA of the host cell, preventing the formation of an aminoacyl-tRNA synthetase complex with tRNA. This prevents the incorporation of amino acids into proteins, leading to inhibition of protein synthesis and cell death. 3'-O-Acetylthymidine also inhibits HIV replication by competing with deoxycytidine triphosphate for incorporation into DNA, preventing the synthesis of viral DNA. 3'-O-Acetylthymidine is hydrolyzed by esterases or glucuronidases, oxidized by cytochrome P450 enzymes, reduced by glutathione reductase

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 284.27 g/mol
• Formel: C₁₂H₁₆N₂O₆
• Reinheit: Min. 98 Area-%
• Farbe/Form: White Powder