5'-Amino-5'-deoxyguanosine

CAS: 4099-84-7

Ref. 3D-NA16031

Produktinformation

• Name: 5'-Amino-5'-deoxyguanosine
• Synonyme: 2H-purin-6-ol, 9-(5-amino-5-deoxypentofuranosyl)-3,9-dihydro-2-imino-

Beschreibung

5'-Amino-5'-deoxyguanosine (5-ADG) is an intermediate in the de novo synthesis of guanine nucleotides. It can be synthesized from 5-aminoimidazole ribonucleotide and guanosine monophosphate (GMP). 5-ADG is a substrate for the enzyme GTP cyclohydrolase, which converts it to GMP. This intermediate can also be formed by the action of phosphoryl chloride on 5-aminoimidazole ribonucleotide. The reaction of 5-ADG with malonic acid leads to the formation of inosinic acid, which has been postulated to be a precursor of purines. This conversion is catalyzed by adenylosuccinate synthetase and the enzyme adenylosuccinase.

The reaction mechanism for this reaction includes two steps: a substitution step and a ligation step. In

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 282.26 g/mol
• Formel: C₁₀H₁₄N₆O₄
• Reinheit: Min. 95 Area-%
• Farbe/Form: Powder