2',3'-Anhydrothymidine

CAS: 14486-22-7

Ref. 3D-NA165900

Produktinformation

• Name: 2',3'-Anhydrothymidine
• Synonyme: 1-(2,3-Anhydro-b-D-lyxofuranosyl)-thymine
• Marke: Biosynth
• Beschreibung: 2',3'-Anhydrothymidine is a nucleoside analogue that has been shown to inhibit HIV-1 transcriptase and polymerase by binding to the enzyme's active site. It also inhibits DNA synthesis in human cells and inhibits the growth of E. coli. 2',3'-Anhydrothymidine is a prodrug that can be taken up by cells, where it is converted into an epoxide, which then binds to the enzyme's active site. This prevents the enzyme from catalyzing reactions and terminating DNA synthesis at the correct point during transcription. 2',3'-Anhydrothymidine may also have immunodeficiency-related benefits due to its ability to bind more tightly to dsDNA than natural nucleotides, causing termination of RNA synthesis at the wrong point.

Chemische Eigenschaften

• Molekulargewicht: 240.21 g/mol
• Formel: C₁₀H₁₂N₂O₅
• Reinheit: Min. 95%