Ethyl (4-chlorophenyl)(hydroxy)acetate

CAS: 13511-29-0

Ref. 3D-NAA51129

Produktinformation

• Name: Ethyl (4-chlorophenyl)(hydroxy)acetate

Beschreibung

Ethyl (4-chlorophenyl)(hydroxy)acetate is a chiral, enantioselective, catalytic, and efficient synthetic reagent for the arylation of ketones. It has been used as an intermediate in the synthesis of various pharmaceuticals. This compound is prepared by reacting ethyl 4-chloroacetate with hydroxylamine and glyoxal in the presence of an acidic catalyst. The reaction proceeds via a phosphonium salt that acts as both a catalyst and an enolate trapping agent. This process results in high yield and selectivity for the desired product. A mutant of this compound has been developed that contains phosphite groups instead of chlorides to avoid potential side reactions with metal catalysts.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 214.65 g/mol
• Formel: C₁₀H₁₁ClO₃
• Reinheit: Min. 95%
• Farbe/Form: Powder