2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine

CAS: 135598-68-4

Ref. 3D-NC29827

Produktinformation

• Name: 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine

Beschreibung

2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine is an analog of the natural substrate for DNA cytosine methyltransferase, 5-methylcytosine. 2'-Cyano-2'-deoxy-1-(b-D-arabinofuranosyl)cytosine inhibits the enzyme activity of DNA methyltransferase and blocks cell proliferation. It has been shown to be a potent antitumor agent in experimental models and may serve as a potential biomarker for cancer treatment. The drug is an oral prodrug that is activated by deamination in the liver and kidneys to release the active form, 5'-Azacytidine monophosphate (5'AZA). This metabolite then inhibits DNA methylation by binding to DNA cytosine methyltransferase, resulting in a loss of function of this enzyme.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 252.23 g/mol
• Formel: C₁₀H₁₂N₄O₄
• Reinheit: Min. 95%