2'-Deoxyadenosine monohydrate

CAS: 16373-93-6

Ref. 3D-ND04011

Produktinformation

• Name: 2'-Deoxyadenosine monohydrate
• Synonyme: 9-(2-Deoxy-β-D-ribofuranosyl)adenine monohydrate2'-Deoxy-D-adenosine monohydrate(2R,3S,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymet hyl)tetrahydrofuran-3-ol monohydrate, 2-Deoxyadenosine monohydrate, 2-deoxyadenosine 2-Deoxyadenosine, 2'-Deoxyadenosine Hydrate (1:1)
• CAS: 16373-93-6

Beschreibung

2'-Deoxyadenosine monohydrate (2'-dA) is an adenosine nucleotide that is synthesized by the enzyme adenosine kinase. It is a competitive inhibitor of phosphodiesterase and inhibits the activity of this enzyme, which breaks down cyclic nucleotides to their corresponding monophosphate form. This leads to elevated levels of cAMP, which can cause neuronal death by apoptosis. 2'-dA has been shown to have sublethal effects on neurons at concentrations that are below those required for neuronal death and apoptosis. This may be due to its ability to inhibit the synthesis of ATP, thereby limiting the production of phosphoryl groups from ATP. The inhibition of ATP synthesis also reduces the amount of energy available for other processes within cells.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 269.26 g/mol
• Formel: C₁₀H₁₃N₅O₃•H₂O
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder