2',3'-Dehydro-5'-O-tritylthymidine

CAS: 5964-41-0

Ref. 3D-ND04743

Produktinformation

• Name: 2',3'-Dehydro-5'-O-tritylthymidine
• Synonyme: 5-Methyl-1-(5-tritylmethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione2',3'-Dehydro-5'-O-trityl-D-thymidine

Beschreibung

2',3'-Dehydro-5'-O-tritylthymidine is an anticancer compound, which is a novel nucleoside phosphoramidite. It is synthesized from thymidine in two steps: first, the 2',3'-dideoxyribose phosphate moiety is prepared by reacting 2',3'-dideoxyribose with chloroacetic acid in the presence of triethylamine, followed by reaction with trityl chloride to form the 5' position of the thymidine. 2',3'-Dehydro-5'-O-tritylthymidine has been shown to inhibit DNA synthesis and antiviral activity.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 466.54 g/mol
• Formel: C₂₉H₂₆N₂O₄
• Reinheit: Min. 95%
• InChl: InChI=1S/C29H26N2O4/c1-21-19-31(28(33)30-27(21)32)26-18-17-25(35-26)20-34-29(22-11-5-2-6-12-22,23-13-7-3-8-14-23)24-15-9-4-10-16-24/h2-19,25-26H,20H2,1H3,(H,30,32,33)
• InChI Key: InChIKey=MIAKIEAKHPFXJJ-UHFFFAOYSA-N
• SMILES: Cc1cn(C2C=CC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)O2)c(=O)[nH]c1=O