9-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)guanine

CAS: 103884-98-6

Ref. 3D-ND08478

Produktinformation

• Name: 9-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)guanine
• Synonyme: 2'-FANA-G, 2-Amino-9-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one, 2-Amino-9-[(3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-D-arabinofuranosyl)-3,9-dihydro-6H-purin-6-one, 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">D</span>-arabinofuranosyl)-1,9-dihydro-, 6H-Purin-6-one, 2-amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1,9-dihydro-, 9-β-D-[2'-Fluoro-2'-deoxy-arabinofuranosyl]-guanin, Nuk-2, 2-Amino-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-1,9-dihydro-6H-purin-6-one, 2′-Fluoro-Arabinoguanosine

Beschreibung

9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine is a nucleoside phosphorylase inhibitor that is used to treat inflammatory bowel disease. It has been shown to be effective in treating women with inflammatory bowel disease, and has no significant side effects. 9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine inhibits the bacterial enzyme nucleoside phosphorylase, which is responsible for the conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP). This inhibition prevents the synthesis of DNA and RNA by blocking the conversion of GTP and GDP into AMP and GMP. The drug binds to the active site of nucleoside phosphorylase, which is located in the bacterial cytoplasmic membrane. 9-(2'-Deoxy-2'-fluoro

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 285.24 g/mol
• Formel: C₁₀H₁₂FN₅O₄
• Reinheit: Min. 97 Area-%
• Farbe/Form: Powder