5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt

CAS: 120912-54-1

Ref. 3D-ND08934

Produktinformation

• Name: 5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt
• Synonyme: 5,6-Dichloro-1-Beta-D-Ribofuranosylbenzimidazole-3’,5’-Monophosphorothioate, 5,6-Dichlorobenzimidazoleriboside-3’,5’-Monophosphorothioate,Sp-Isomer(Sp5,6-Dcl-Cbimps),, Sp-5,6-Dichloro-1-Beta-D-Ribofuranosylbenzimidazole-3',5'-Monophosphorothioate, 5,6-Dichloro-1-B-D-ribofuranosylbenzimidazole-3',5'-cyclic monophosphothioa, 5,6-Dichloro-1-b-D-ribofuranosylbenzimidazole-3μ,5μ-cyclic monophosphorothioate, Sp- isomer sodium salt, 5,6-Dcl-Cbimpsasp-Isomer, sodium (4aR,6R,7R,7aS)-6-(5,6-dichloro-1H-benzimidazol-1-yl)-7-hydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-sulfide

Beschreibung

5,6-Dichloro-(1-b-D-ribofuranosyl) benzimidazole 3',5'-cyclic monophosphothioate, Sp-isomer sodium salt (SPP) is a cytostatic agent that binds to the α subunit of the voltage-dependent Ca2+ channel. It has been shown to inhibit tumor growth in mouse models of hyperproliferative diseases such as bladder cancer and pulmonary fibrosis. SPP also inhibits the proliferation of human bladder cells in culture by inhibiting cyclic nucleotide phosphodiesterase activity. This leads to an increase in intracellular calcium concentrations and activation of cation channels. SPP is an analog of rolipram, which has been shown to have anti-inflammatory effects on detrusor muscle cells.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 419.16 g/mol
• Formel: C₁₂H₁₀Cl₂N₂O₅P·Na
• Reinheit: Min. 95%