1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil

CAS: 144822-63-9

Ref. 3D-ND09139

Produktinformation

• Name: 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil
• Synonyme: 1-{5-O-[Bis-(4-methoxyphenyl)-phenylmethyl]-2-deoxy-2-fluoro--D-arabinofuranosyl}-2,4(1H,3H)-pyrimidinedione, 1-[(3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

Beschreibung

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil (1FdUMP) is a synthetic, modified nucleoside that is an antimetabolite. It inhibits DNA synthesis by reacting with the phosphate groups of the deoxyribose sugar, which are needed for DNA synthesis. 1FdUMP is phosphorylated to form 1FdUMP monophosphate and 1FdUMP diphosphate, which are intermediates in DNA synthesis. The phosphoramidites of 1FdUMP can be used to synthesize oligonucleotides for use in research and clinical applications such as anticancer drugs, antiviral agents, or anti-inflammatory agents.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 548.56 g/mol
• Formel: C₃₀H₂₉FN₂O₇
• Reinheit: Min. 95%
• Farbe/Form: White To Off-White Solid