N-(2'-Deoxyguanosin-8-yl)-4-amino(biphenyl)

CAS: 84283-08-9

Ref. 3D-ND11672

Produktinformation

• Name: N-(2'-Deoxyguanosin-8-yl)-4-amino(biphenyl)
• Synonyme: DG-C8-ABP8-(4-Biphenylylamino)-2'-deoxyguanosine
• Marke: Biosynth
• Beschreibung: N-(2'-Deoxyguanosin-8-yl)-4-amino(biphenyl) (NGB) is a genotoxic compound that causes mutations in mammalian cells. It has been shown to cause cancer in rats, and it is carcinogenic in the bladder of both rats and humans. NGB is also mutagenic to the wild-type strain of bacteria, which may be due to its ability to affect DNA replication. This drug has been detected in human urine at levels as high as 2 micrograms per milliliter and has been found in tissues of mammals, including humans. NGB binds tightly to eicosatetraynoic acid (ETYA), a fatty acid that is an intermediate product of lipid metabolism, which may account for its genotoxic effects.

Chemische Eigenschaften

• Molekulargewicht: 434.45 g/mol
• Formel: C₂₂H₂₂N₆O₄
• Reinheit: Min. 95%