3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine

CAS: 1582-79-2

Ref. 3D-ND22463

Produktinformation

• Name: 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine
• Synonyme: 2'-Deoxy-5-fluoro-uridine 3',5'-bis(4-chlorobenzoate)3,5-Di-O-p-chlorobenzoyl floxuridine
• Marke: Biosynth
• Beschreibung: 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine is a nucleoside derivative that has antiviral activity. It is synthesized by the condensation of 2,3,5-trihydroxybenzoic acid with 3'-chloro-5'-fluoroacetophenone in the presence of pyridine and triethylamine. The nucleoside has been shown to be an effective inhibitor of HIV replication in vitro. 3',5'-Di-O-p-chlorobenzoyl-2'-deoxy-5-fluorouridine also inhibits DNA synthesis in human lymphocytes at concentrations of 5 μM or less. This compound can be used as an activator for DNA polymerases and phosphoramidites for DNA synthesis.

Chemische Eigenschaften

• Molekulargewicht: 523.29 g/mol
• Formel: C₂₃H₁₇Cl₂FN₂O₇
• Reinheit: Min. 95%