2'-Deoxy-5-formyluridine

CAS: 4494-26-2

Ref. 3D-ND29039

Produktinformation

• Name: 2'-Deoxy-5-formyluridine
• Synonyme: 1-(2-Deoxypentofuranosyl)-2,4-Dioxo-1,2,3,4-Tetrahydropyrimidine-5-Carbaldehyde, 5-Formyl-2′-deoxyuridine, 5-Formyldeoxyuridine, 5-Fromyl-2'-Deoxyuridine, 5-Pyrimidinecarboxaldehyde, 1-(2-Deoxypentofuranosyl)-1,2,3,4-Tetrahydro-2,4-Dioxo-, 5-Pyrimidinecarboxaldehyde, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-erythro-pentofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-, 5-Pyrimidinecarboxaldehyde, 1-(2-deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-1,2,3,4-tetrahydro-2,4-dioxo-, NSC 148297, Thymidine, α-oxo-, Uridine, 2'-Deoxy-5-Formyl-, α-Oxothymidine

Beschreibung

2'-Deoxy-5-formyluridine (2DFO) is a nucleobase analogue that inhibits the enzymatic activity of DNA glycosylases, which are enzymes that remove sugar residues from damaged DNA. 2DFO has been shown to induce apoptosis in cancer cells by inhibiting DNA synthesis and promoting oxidative damage to the cell's DNA. 2DFO has also been shown to inhibit the growth of DU-145 cells in vitro and in vivo models. This drug was found to be more effective at preventing metastasis of colorectal cancer when it was administered with a platinum-based chemotherapy drug.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 256.21 g/mol
• Formel: C₁₀H₁₂N₂O₆
• Reinheit: Min. 95 Area-%
• Farbe/Form: White Off-White Powder