Denufosol tetrasodium

CAS: 318250-11-2

Ref. 3D-ND45968

Produktinformation

• Name: Denufosol tetrasodium
• Synonyme: 2'-Deoxycytidine P'''-5'-ester with uridine 5'-(pentahydrogen tetraphosphate) sodium saltUridine 5'-(pentahydrogen tetraphosphate), P'5'-ester 2'-deoxycytidineINS 37217[[(3S,5R)-5-(4-Amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyp
• Marke: Biosynth
• Beschreibung: A P2Y2 receptor agonist that has been studied in cystic fibrosis and retinal diseases such as retinal detachment. Denufosol was studied as an inhaled drug for cystic fibrosis, due to its ability to activate an alternative chloride channel and avoiding the defective CFTR chloride channel. This enhances hydration of the lung mucosa and improves mucociliary clearance. The drug did not progress from phase III clinical trials. Denufosol resulted in subretinal fluid reabsorption in in vivo model of retinal detachment.

Chemische Eigenschaften

• Molekulargewicht: 861.25 g/mol
• Formel: C₁₈H₂₃N₅Na₄O₂₁P₄
• Reinheit: Min. 90 Area-%
• Farbe/Form: Powder