Fludarabine

CAS: 21679-14-1

Ref. 3D-NF05140

Produktinformation

• Name: Fludarabine
• Synonyme: 2-Fluoro-9-(b-D-arabinofuranosyl)adenine2-F-araA9-b-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine(2R,3S,4S,5R)-2-(6-Amino-2-fluoro -9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Fluoro Ara-A, 2-Fluoro-9-β-<span class="text-smallcaps">D</span>-arabinofuranosyladenine, 2-Fluoro-9-β-D-arabinofuranosyladenine, 2-Fluoroadenine arabinoside, 2-Fluoroadenine-9-bata-D-arabinofuranoside, 2F-Ara-A, 9-(beta-D-arabinofuranosyl)-2-fluoro-9H-purin-6-amine, 9-bata-D-Arabinofuranosyl-2-fluoroadenine, 9-beta-D-Arabinofuranosyl-2-fluoroadenine, 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-2-fluoro-9H-purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-2-fluoroadenine, 9-β-<span class="text-smallcaps">D</span>-Arabinosyl-2-fluoroadenine, 9-β-D-Arabinofuranosyl-2-fluoroadenine, 9-β-D-Arabinosyl-2-fluoroadenine, 9H-Purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2-fluoro-, 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-2-fluoro-, Adenine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-2-fluoro-, Adenine, 9-β-D-arabinofuranosyl-2-fluoro-, F-ara-A, Fludarabin, Fludarabina, Fludarabine base, Nsc 118218, Nsc 118218H, 9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine

Beschreibung

Fludarabine is an equilibrative nucleoside analog that inhibits DNA synthesis by blocking the enzyme ribonucleotide reductase. It is a potent inducer of apoptosis and has been used in autologous stem-cell transplantation for leukemia. Fludarabine has significant up-regulation of Bcl-2 protein levels, which may be responsible for its potent induction of apoptosis. Fludarabine also has a number of drug interactions, including the ability to inhibit the metabolism of other drugs through inhibition of cytochrome P450 enzymes. Fludarabine is not active against opportunistic fungal infections.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 285.23 g/mol
• Formel: C₁₀H₁₂FN₅O₄
• Reinheit: Min. 95%
• Farbe/Form: White Powder