N1-Methylguanosine

CAS: 2140-65-0

Ref. 3D-NM08574

Produktinformation

• Name: N1-Methylguanosine
• Synonyme: N1-Methyl-D-guanosine, 2-amino-1-methyl-9-pentofuranosyl-1,9-dihydro-6H-purin-6-one, Guanosine, 1-Methyl-, Methylguanosine, N¹-Methylguanosine, NSC 70897, 1-Methylguanosine

Beschreibung

N1-Methylguanosine is a methylated nucleotide that is incorporated into the growing DNA chain during protein synthesis. The incorporation of N1-methylguanosine into the growing DNA chain can cause frameshifting, which creates an unusual amino acid sequence. This effect has been shown in model organisms, such as Saccharomyces cerevisiae and Escherichia coli. In these organisms, N1-methylguanosine has been shown to induce cancer when added to the growth medium. It is also found in urine samples from people with bladder cancer and has been used to identify urinary tract cancers. Titration calorimetry studies have shown that N1-methylguanosine binds to a chelate ligand and forms a disulfide bond with cysteine residues on proteins or peptides, which may lead to mitochondrial dysfunction by interfering with hydrogen bonding interactions. Messenger RNA studies show that N1-methylguanosine inhibits translation of mRNA by binding to

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 297.27 g/mol
• Formel: C₁₁H₁₅N₅O₅
• Reinheit: Min. 95%
• Farbe/Form: White Powder