4-Thiouridine

CAS: 13957-31-8

Ref. 3D-NT06186

Produktinformation

• Name: 4-Thiouridine
• Synonyme: 4-Thio-D-uridine, 1-beta-D-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one, 1-pentofuranosyl-4-thioxo-3,4-dihydropyrimidin-2(1H)-one, Nsc 518132, Thiouridine, Thiouridine (VAN), Uridine, 4-thio-

Beschreibung

4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analogue that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labelling. 4-SU is typically used to modify RNA oligonucleotides, or in structure studies of RNA-protein complexes. The crosslinking thiol moiety is attached directly to the nucleotide base, thus 4-SU differs from the nucleoside uridine only by a single sulfur substitution. This means it can be incorporated into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will significantly impair RNA interactions or activities.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 260.27 g/mol
• Formel: C₉H₁₂N₂O₅S
• Reinheit: Min. 98 Area-%
• Farbe/Form: Powder