Ganglioside GM1

CAS: 37758-47-7

Ref. 3D-OG03918

Produktinformation

• Name: Ganglioside GM1
• Synonyme: Gal(b1-3)GalNAc(b1-4)[Neu5Ac(a2-3)]Gal(b1-4)Glc(b1-1)CersMonosialogangl ioside GM1prototype gangliosidemonosialotetrahexosylganglioside Ganglioside Monosialotetrahexosylganglioside
• Marke: Biosynth
• Beschreibung: Ganglioside GM1 has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the inner galactose residue, ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009), and is abundant in all mammalian brains, where it covers 10%-20% of the total ganglioside mixture. Ganglioside GM1 is found in epithelial membranes and is a key element for the detection of bacterial toxicity and viral infection. It is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin (LTB) from E.coli, for rotavirus, and simian virus 40. GM1 functions as a neurotrophic and neuroprotective compound and has been used therapeutically for diabetic and peripheral neuropathies. It also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Chemische Eigenschaften

• Molekulargewicht: 1,546.82 g/mol
• Formel: C₇₃H₁₃₁N₃O₃₁·xNa
• Reinheit: Min. 95 Area-%
• Farbe/Form: White Powder