GT1b-Ganglioside sodium

CAS: 59247-13-1

Ref. 3D-OG03923

Produktinformation

• Name: GT1b-Ganglioside sodium
• Synonyme: Cer-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAcGT1b-Ganglioside
• Marke: Biosynth
• Beschreibung: GT1b (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with two sialic acids (NeuAc) linked α2,3/α2,8 to the inner galactose residue, sialic acid (NeuAc) linked α2,3 to the terminal galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GT1b is one of the major gangliosides in neuronal and glial membranes, it interacts with the myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GT1b ganglioside also acts as a receptor for bacterial toxins, such as, tetanus and botulinum toxins (Nishik,i 1996), as well as for viruses, a few examples include: Merkel cell polyomavirus, JC virus, BK virus, norovirus, and others (Low, 2006).

Chemische Eigenschaften

• Molekulargewicht: 2,145.33 g/mol
• Formel: C₉₅H₁₆₅N₅O₄₈·xNa
• Farbe/Form: White Powder