GD2-Ganglioside

CAS: 65988-71-8

Ref. 3D-OG06830

Produktinformation

• Name: GD2-Ganglioside
• Synonyme: Disialoganglioside-GD2, 65988-71-8, Disialoganglioside GD₂, G_D2, Ganglioside G_D2

Beschreibung

GD2 (shown as sodium salt) has a core trisaccharide structure (GalNAc-b-1,4-Gal-b-1,4-Glc) with its two sialic acids linked b-2,3/b-2,8 to the inner galactose residue and ceramide linked to position 1 on the reducing terminal glucose residue. GD2 ganglioside is expressed at a low concentration in the central nervous system, nerves, skin melanocytes and stem cells in healthy adults. On the other hand, GD2 is overexpressed in a number of tumors, including: neuroblastoma, melanoma, small cell lung carcinoma and brain tumors. Recently, it has been found in low concentrations on breast cancer stem cells (CSC) that possess: self-renewal properties (division without disrupting the undifferentiated state), and tumor-initiating capabilities. It has been suggested that GD2 ganglioside may be developed as an effective target antigen for CSC immunotherapy (Fleurence, 2017).

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,675.94 g/mol
• Formel: C₇₈H₁₃₈N₄O₃₄·xNa
• Reinheit: Min. 95 Area-%
• Farbe/Form: Powder