GM3-Ganglioside labelled by NBD ammonium

Ref. 3D-OG09793

Produktinformation

• Name: GM3-Ganglioside labelled by NBD ammonium
• Synonyme: N-Acetyl-a-D-neuraminic acid)-(2->3)-O-b-D-galactopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->1)-(2S,3R,4E)-2-N-(7-nitrobenz-2-oxa-1,3 -diazol-4-yl)aminooctanamido-4-octadecene-1,3-diol ammonium saltaNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer linked 7-n

Beschreibung

GM3-ganglioside NBD (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue with nitrobenzoxadiazole (NBD) linked β to position 1 on the reducing terminal glucose residue, in place of the ceramide fatty acid (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain, and melanomas, where it is frequently found to be overexpressed. GM3 ganglioside is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function, and immune disorders (e.g. allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and is a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,236.36 g/mol
• Formel: C₅₅H₉₀N₆O₂₄·H₃N
• Reinheit: Min. 95%
• Farbe/Form: Powder