GM2-Ganglioside

CAS: 19600-01-2

Ref. 3D-OG16187

Produktinformation

• Name: GM2-Ganglioside
• Synonyme: Monosialoganglioside GM2, G_M2, G_M2-ganglioside, GM2, Ganglioside A1, Ganglioside A₁, Ganglioside G5, Ganglioside G₅, Ganglioside G_M2, Ganglioside G_O, Ganglioside GM₂, Ganglioside GO, Ganglioside M2, Sialosylganglio-N-triaosylceramide, Tay-Sachs ganglioside, Monosialoganglioside GM2 bovine brain

Beschreibung

GM2 ganglioside (sodium salt) has a core trisaccharide structure (GalNAcβ1,4Galβ1,4Glc) with sialic acid linked α2,3 to the central galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). GM2 ganglioside is present on neuronal cells and plays a key role in the regulation of dendritogenesis in cortical pyramidal neurons. In lysosomal storage disorders, such as, Tay-Sachs and Sandhoff disease, where hexosaminases A and B are deficient, GM2 ganglioside accumulates in the nervous system (Cachon-Gonzalez, 2018). GM2 ganglioside is also overexpressed in melanomas and other tumours of neuro-ecto origin (Yoshida, 2020). Moreover, the sugar moiety of the GM2 ganglioside is a receptor allowing the viral infection of cells with reovirus and rotavirus (Zhu, 2018).

• Marke: Biosynth

Chemische Eigenschaften

• Reinheit: Min. 96%
• Farbe/Form: Powder