GM3-Ganglioside sodium

CAS: 54827-14-4

Ref. 3D-OG16188

Produktinformation

• Name: GM3-Ganglioside sodium
• Synonyme: aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer, G_Lac1, G_M3, GLac1, GM3, Ganglioside G_M3, Ganglioside M3, Ganglioside M₃, Gangliosides, GM3, Hematoside, Monosialodihexosylganglioside, Sialosyllactosylceramide

Beschreibung

Ganglioside GM3 (sodium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as: lung, brain and melanomas, where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function and immune disorders (e.g., allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,252 g/mol
• Formel: C₆₄H₁₁₈N₂O₂₁·xNa
• Reinheit: Min. 98 Area-%
• Farbe/Form: White Powder