GM3-Ganglioside ammonium

CAS: 54827-14-4

Ref. 3D-OG175970

Produktinformation

• Name: GM3-Ganglioside ammonium
• Synonyme: G_Lac1, G_M3, GLac1, GM3, Ganglioside G_M3, Ganglioside M3, Ganglioside M₃, Gangliosides, GM3, Hematoside, Monosialodihexosylganglioside, Sialosyllactosylceramide
• CAS: 54827-14-4

Beschreibung

Ganglioside GM3 (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked a2,3 to the galactose residue and ceramide linked β to position 1 on the reducing terminal glucose residue (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain and melanomas where it is over expressed. It is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganlioside is implicated in various other diseases involving chronic inflammation, such as, insulin resistance, leptin resistance, T-cell function and immune disorders (e.g. allergic asthma). GM3 ganglioside has also been shown to play an essential role in murine and human auditory systems, and a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,198.52 g/mol
• Formel: C₅₉H₁₁₁N₃O₂₁xNH₄
• Reinheit: Min. 95%