Lipid IVa

CAS: 91841-27-9

Ref. 3D-OL09566

Produktinformation

• Name: Lipid IVa
• Synonyme: Lipid A 406, LA-14-PP, Precursur 1a, Lipid IVa triethylammonium

Beschreibung

Lipid IVA is a tetra-acylated precursor molecule of lipid A which is a component of lipopolysaccharides (LPS) on the outer membrane of gram-negative bacteria. On the innate immune cells of hosts there are toll-like receptor 4 (TLR4) and MD-2 which recognize LPS. This recognition event ultimately leads to the activation of NFκB which in turn results in pro-inflammatory cytokine production. Studies have suggested lipid A in Escherichia coli to be an agonist for both mouse and human TLR4, while lipid IVA can induce species specific TLR4 responses. For example for horse and mouse TLR4 and MD-2, Lipid IVA is an agonist where as it is an antagonist for TLR4 and MD-2 in humans.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 1,405.7 g/mol
• Formel: C₆₈H₁₃₀N₂O₂₃P₂
• Reinheit: One Main Spot
• Farbe/Form: White Powder