GD1a-Oligosaccharide

CAS: 71494-27-4

Ref. 3D-OO35336

Produktinformation

• Name: GD1a-Oligosaccharide
• Synonyme: GD1aSaccharide
• Marke: Biosynth
• Beschreibung: GD1a oligosaccharide is the carbohydrate moiety from the disialylated glycosphingolipid GD1a of the a-series (shown in the sodium form), a major ganglioside found in neuronal and glial membranes. GD1a oligosaccharide has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with sialic acids linked α2,3/α2,8 to the inner galactose residue, α2,3 to the outer galactose residue (Ledeen, 2009). GD1a ganglioside interacts with myelin-associated glycoprotein (MAG) and is essential for long-term axon-myelin stability. GD1a ganglioside plays a role in viral infection as it is a receptor for viral glycoproteins in rotavirus and paramyxovirus 1. The hexasaccharide GD1a moiety was also found on a glycoprotein that acts as a receptor for adenovirus type 37. Additionally, GD1a ganglioside interacts with botulinum neurotoxin (BoNT) and is crucial for its entry into cells (Kolter, 2012).

Chemische Eigenschaften

• Molekulargewicht: 1,290.14 g/mol
• Formel: C₄₈H₇₉N₃O₃₇
• Reinheit: Min. 95%
• Farbe/Form: Powder