N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite

CAS: 163759-94-2

Ref. 3D-PB64062

Produktinformation

• Name: N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite
• Synonyme: 5-Me-DMT-2'-O-MOE-C(Bz)-CEP, 5-Me-DMT-2'-O-MOE-C(Bz)-CE Phosphoramidite, 2'-O-Methyl-N4-Benzoyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite, N4-Benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine-3'-cyanoethyl Phosphoramidite

Beschreibung

Nucleoside phosphoramidites are used in the chemical synthesis of oligonucleotides. Using a chemical approach rather than an enzymatic one allows quick and inexpensive access to custom-made oligonucleotides of the desired sequence. Differently from the enzymatic synthesis, the chemically synthesised oligonucleotide sequence is typically constructed in a 3’ to 5’ direction. N4-Benzoyl-5'-O-DMT-2'-O-(2-methoxyethyl)-5-methylcytidine 3'-CE phosphoramidite, also called 5-Me-DMT-2'-O-MOE-C(Bz)-CEP, has been used in the synthesis of oligonucleotides which are specifically hybridizable with nucleic acids encoding multidrug resistant-associated protein (MRP). The antisense oligonucleotide ISIS 13041 gave almost complete removal of resistance to vincristine, a chemotherapy drug.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 922.01 g/mol
• Formel: C₅₀H₆₀N₅O₁₀P
• Reinheit: Min. 95%
• Farbe/Form: White Powder