2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite

CAS: 125258-62-0

Ref. 3D-PD09127

Produktinformation

• Name: 2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite
• Synonyme: 1-(2'-Deoxy-5'-O-DMT-b-D-ribofuranosyl)-5-methyl-2-pyrimidinone 3'-CE phosphoramidite, 2(1H)-Pyrimidinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-, 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-2(1H)-pyrimidinone

Beschreibung

2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite is a novel nucleoside that has been modified to contain a 5-methyl group at the 2′ position. It is phosphorylated with a phosphate group at the 3′ position and linked to an oligonucleotide via a 3′-O,O′-dimethoxytrityl (DMT) spacer. This novel nucleoside has antiviral activity against hepatitis C virus and cytomegalovirus, as well as anticancer properties. 2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite has shown antitumour activity in animal models of human breast cancer and melanoma.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 728.81 g/mol
• Formel: C₄₀H₄₉N₄O₇P
• Reinheit: Min. 95%
• Farbe/Form: Solid