Produktinformation
- Brl 44385
- 2-Amino-1,9-dihydro-9-(3-hydroxypropoxy)-6H-purin-6-one
- 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(3-hydroxypropoxy)-
- 2-amino-9-(3-hydroxypropoxy)-3,9-dihydro-6H-purin-6-one
- 9-(3-Hydroxypropoxy)guanine
9-(3-Hydroxypropoxy)guanine is an aldehyde oxidase inhibitor that blocks the production of formaldehyde, which is a reactive metabolite that can cause DNA damage. 9-(3-Hydroxypropoxy)guanine has been shown to inhibit the oxidation of purines in incubations with c1-6 alkyl. It also inhibits the oxidation of guanine and deoxyguanine mediated by aldehyde oxidase. This drug is a prodrug, which is converted to its active form in the cytosol by cytochrome p450 enzymes. The metabolic transformation of 9-(3-hydroxypropoxy)guanine into its active form occurs primarily in hepatocytes. 9-(3-Hydroxypropoxy)guanine has been shown to be effective against oxidative stress induced by homogenates and liver cells from humans, as well as cytosolic extracts from human hepatocytes.
Chemische Eigenschaften
Technische Anfrage zu: 3D-PEA77860 9-(3-Hydroxypropoxy)guanine
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