Lapaquistat acetate
CAS: 189060-13-7
Ref. 3D-PHA06013
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Produktinformation
- 1-((1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2\r
- ,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid
- 1-[2-[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid
- 2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3- dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3- yl)acetyl)piperidin-4-yl)acetic acid
- 4-Piperidineacetic acid, 1-(((3R,5S)-1-(3-(acetyloxy)-2,2-dimethylpropyl)-7- chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3- yl)acetyl)-
- 4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-
- 4-Piperidineacetic acid, 1-[[1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-, (3R-trans)-
- Lapaquistat acetate [USAN]
- Tak 475
- Unii-Iuh3Ay74O3
- Mehr Synonyme anzeigen
LAPAQ is a hydroxyl-containing fatty acid that is synthesized by the liver and is used as a co-therapy for lowering low-density lipoprotein cholesterol. LAPAQ has been shown to have a chemical stability that is 8 times higher than that of other drugs, which may be due to its ester linkages. This drug also has anti-inflammatory properties, which are due to its ability to inhibit the production of high-sensitivity c-reactive protein (hsCRP). LAPAQ inhibits the activity of 3 enzymes involved in cholesterol synthesis, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG CoA reductase), acetyl coenzyme A cholesterol acyltransferase (ACAT), and lysophospholipid acyltransferase. It also inhibits the transcriptional regulation of low density lipoprotein cholesterols.
Chemische Eigenschaften
Technische Anfrage zu: 3D-PHA06013 Lapaquistat acetate
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