TRH peptide

Ref. 3D-PP51154

Produktinformation

• Name: TRH peptide
• Synonyme: pQ-HP-NH2

Beschreibung

Protirelin - Thyrotropin-releasing hormone (TRH) (CAS: 24305-27-9)

Thyrotropin-releasing hormone (TRH)

Thyrotropin-releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone that regulates the release of thyroid-stimulating hormone (TSH), as well as prolactin (for breasts growth and milk production during and after pregnancy).

To obtain thyrotropin-releasing hormones, 6 pro-TRH peptides have first to be obtained from the larger preproTRH precursor (UniProt: P20396). These octapeptides are then cleaved between Arginine/Glutamine and Glutamine/Lysine residues to release 6 Gln-His-Pro-Gly peptides that will be enzymatically converted in pGln-His-Pro-NH2 peptides (pGln representing pyroglutamine).

After TRH maturation (1) in neurons located in the pituitary gland, the hormone will be transported along axons (2) to reach the hypophyseal portal system via exocytosis (3). Once the thyrotrophs reached, thyrotropin-releasing hormone binds TRH-receptor (4) to enable TSH synthesis and secretion that will stimulate thyroid follicular cells to produce thyroid hormones Triiodothyronine (T3) and Tetraiodothyronine (T4).

[Glu2]-TRH_pGluGLuPro-NH2_CAS: 85541-78-2_ and TRH peptide_CAS: 24305-27-9_SB-PEPTIDE scheme: TRH metabolism pathway

TRH implication in hypothyroidism and cholinergic neuronal activity

TRH being directly involved in TSH release, deficiency of this hormone has been found to be related to secondary hypothalamic hypothyroidism. This condition can affect all body functions, causing various symptoms of different severity from fatigue to brittle nails, cold intolerance or joint pain even.

On the contrary, even though no case of excessively high levels of TRH was observed up to now, studies showed the cholinergic effect of TRH in mouse brain. In 1991, for instance, M. G. Giovannini & al. associated TRH administration, s.c. or via local perfusion, with acetylcholine (ACh) release increase from rodents’ cortex and hippocampus, which suggested the strong stimulant action of TRH on cortical and hippocampal cholinergic pathways.

TRH applications

TRH is indicated as adjunctive agent in the diagnostic of potential thyroid disfunction. Even though TRH stimulation test isn’t yet approved by the U.S. Food and Drug Administration (FDA), the intravenous injection of the hormone to the patient’s bloodstream is sometimes used to distinguish different types of thyroid problems. Due to the concern expressed by the FDA, TRH is primarily used as a research tool mainly in the United States.

Besides its role in endocrinology, the ability of TRH to promote wound healing by accelerating skin’s re-epithelization has also been demonstrated a few years ago.

• Marke: Biosynth