Produktinformation
MF498 is a guanylate kinase inhibitor. It has been shown to have potent antagonist activity against toll-like receptor 4 and 5, which are receptors that can be activated by bacterial products such as lipopolysaccharide. MF498 also inhibits the production of inflammatory cytokines such as TNF-α and IL-6, which are involved in chronic inflammatory diseases such as rheumatoid arthritis. MF498 has been shown to inhibit the matrix metalloproteinase-9 (MMP-9) which is an enzyme that breaks down collagen in joints. The drug may be effective for treating conditions where the MMP-9 levels are elevated, such as osteoarthritis or chronic arthritis. MF498 has been shown to inhibit the synthesis of DNA and protein in cancer cells, leading to tumor cell death.
MF498 is a heterobicyclic compound with a molecular weight of 335 daltons. It binds to the guanylate kinase enzyme at its
Chemische Eigenschaften
Technische Anfrage zu: 3D-QLB19142 MF498
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