N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide

CAS: 1316652-41-1

Ref. 3D-RCC65241

Produktinformation

• Name: N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide

Beschreibung

N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide (NHTB) is a histone deacetylase inhibitor that binds to the active site of the enzyme and inhibits its activity. It is selective for class I HDACs over class II HDACs. NHTB has been shown to inhibit acetylation of α-tubulin in vitro and in vivo. The compound also inhibits proliferation of T cells from patients with cutaneous T cell lymphoma and promotes apoptosis. NHTB also has antiangiogenic effects by inhibiting proliferation of endothelial cells.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 326.37 g/mol
• Formel: C₁₆H₁₄N₄O₂S
• Reinheit: Min. 95%