CLEAR-OX™ Resin

Ref. 3D-RCO-1260-PI

Produktinformation

• Name: CLEAR-OX™ Resin

Beschreibung

CLEAR-OXTM is a highly effective polymer-supported reagent for the formation of disulphide bonds. Developed by Peptides International, incorporated to the Cymit Quimica Group through vivitide, CLEAR-OXTM combines the power of solid phase chemistry with the versatility of solution-phase reactions.
CLEAR resin, compatible with both aqueous and organic environments, is transformed to CLEAR-OX through attaching a lysine-preformed cyclic Ellman’s reagent (DTNB) to a CLEAR polymeric support. Since the mechanism is based on peptide capture, sensitive residues such as Tyr, Trp, and Met are not affected, leading to increased purity and yield.
Single disulfide-bridged peptides with constrained amino acids have been successfully produced using CLEAR-OX with various ring sizes and lengths. Oxidations are performed at higher concentrations than solution methods, leading to reduced solvent use at scale. Furthermore, oxidations can be carried out immediately after cleavage with only two-fold CLEAR-OX excess to obtain satisfactory yields. There is also potential for recycling and automation.

• Marke: Biosynth

Chemische Eigenschaften

• Reinheit: Min. 95%