2-Chloro-5-nitronicotinic acid

CAS: 42959-38-6

Ref. 3D-SBA95938

Produktinformation

• Name: 2-Chloro-5-nitronicotinic acid
• Synonyme: 2-Chloro-?5-nitro-3-py?ridine?carboxyli?c acid, 2-Chloro-5-nitropyridine-3-carboxylic acid, 3-Pyridinecarboxylic acid, 2-chloro-5-nitro-, 42959-38-6

Beschreibung

2-Chloro-5-nitronicotinic acid is an inhibitor of HIV-1 reverse transcriptase. It binds reversibly to the active site of the enzyme and blocks its ability to synthesize DNA, thus inhibiting HIV replication. 2-Chloro-5-nitronicotinic acid also inhibits the activity of wild type and mutant forms of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with high potency. This drug has been shown to be effective against nevirapine resistant HIV strains. The molecular modeling studies suggest that 2-chloro-5 nitronicotinic acid binds to a hydrophobic pocket in the active site of HIV reverse transcriptase, which is different from other inhibitors such as AZT, ddI, and ddC.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 202.55 g/mol
• Formel: C₆H₃ClN₂O₄
• Reinheit: Min. 95%