FR 139317

CAS: 142375-60-8

Ref. 3D-SFA37560

Produktinformation

• Name: FR 139317
• Synonyme: <span class="text-smallcaps">D</smallcap>-Alanine, N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl-1-methyl-<smallcap>D</span>-tryptophyl-3-(2-pyridinyl)-, <span class="text-smallcaps">D</smallcap>-Alanine, N-[N-[N-[(hexahydro-1H-azepin-1-yl)carbonyl]-<smallcap>L</smallcap>-leucyl]-1-methyl-<smallcap>D</span>-tryptophyl]-3-(2-pyridinyl)-, Fr 139317, N-(azepan-1-ylcarbonyl)-L-leucyl-1-methyl-D-tryptophyl-3-pyridin-2-yl-D-alanine, N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-<span class="text-smallcaps">L</smallcap>-leucyl-1-methyl-<smallcap>D</smallcap>-tryptophyl-3-(2-pyridinyl)-<smallcap>D</span>-alanine, Pd 147953

Beschreibung

FR 139317 is a selective endothelin receptor antagonist that binds to the endothelin-A receptor, inhibiting its activity. It has been shown to reduce myocardial infarct size and improve cardiac function in an animal model of myocardial infarct. FR 139317 also inhibits the growth of pulmonary artery smooth muscle cells in vitro and reduces endothelin-1 levels in a rat model of primary pulmonary hypertension. This drug also leads to an increase in natriuretic peptide levels and disease activity, as well as decreased blood pressure in rats with renal failure.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 604.75 g/mol
• Formel: C₃₃H₄₄N₆O₅
• Reinheit: Min. 95%