HDAC8-IN-1

CAS: 1417997-93-3

Ref. 3D-SGC99793

Produktinformation

• Name: HDAC8-IN-1
• Synonyme: (2E)-N-Hydroxy-3-(5-methoxy[1,1':4',1''-terphenyl]-2-yl)-2-propenamide
• Marke: Biosynth
• Beschreibung: HDAC8-IN-1 is a small molecule inhibitor of class I histone deacetylases (HDACs). It is a potent inhibitor of HDAC8, the most abundant HDAC in the human genome. In vitro studies have shown that HDAC8-IN-1 inhibits self-renewal and differentiation of cancer stem cells. In vivo, HDAC8-IN-1 treatment inhibited tumor growth in mouse models of leukemia and breast cancer. The pharmacological inhibition of HDAC8 with HDAC8-IN-1 has been shown to inhibit expression of genes involved in cell cycle regulation, angiogenesis, metastasis, and immune suppression.

Chemische Eigenschaften

• Molekulargewicht: 345.39 g/mol
• Formel: C₂₂H₁₉NO₃
• Reinheit: Min. 95%