Melittin

CAS: 20449-79-0

Ref. 3D-TOX-70001-PI

Produktinformation

• Name: Melittin
• Synonyme: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Se r-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2H-GIGAVLKVLTTGLPALISW IKRKRQQ-NH2
• Marke: Biosynth
• Beschreibung: Melittin is a major component of bee venom that has been shown to have antibacterial efficacy against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. It also demonstrates anti-viral activity, for example it inhibits human immunodeficiency virus and herpes simplex virus. Furthermore it can be used in the treatment of inflammatory-related illnesses due to it inhibiting the phospholipase A2 enzyme. In addition to this Melittin's abaility to inhibit inflammatory mediators such as nitric oxide and cyclooxygenase-2 aids in the treatment of inflammatory diseases. As a result of Melittin having the capabilities of attacking lipid membranes and it surpressing COX-2 mRNA expression it can also be used in the treatment of tumours. The bound form of melittin is not toxic to mammalian cells, but it is toxic when it is released into the cell cytoplasm. Melittin has been shown to inhibit transcriptional regulation and locomotor activity in mice. This may be due to its ability to bind DNA, preventing transcription and translation of certain genes. Lastly It has strong hemolytic activity and been seen to increase insulin secretion via depolarization of pancreatic beta-cells. Melittin is a diverse peptide which can be used ina whole spectrum of research and therapeutic areas.

Chemische Eigenschaften

• Molekulargewicht: 2,846.47 g/mol
• Formel: C₁₃₁H₂₂₉N₃₉O₃₁
• Reinheit: Min. 95%