Poly(2'-Fluoro-2'-Deoxyadenylic Acid)

CAS: 68245-92-1

Ref. 3D-TP83535

Produktinformation

• Name: Poly(2'-Fluoro-2'-Deoxyadenylic Acid)
• Marke: Biosynth
• Beschreibung: Poly(2'-Fluoro-2'-Deoxyadenylic Acid) (PFDAA) is a synthetic analog of natural RNA polymerase II α subunit. It has been shown to be a potent inhibitor of protein synthesis in vitro, with an IC50 of 1 μM. PFDAA has been used as a primer in PCR reactions and as a template for transcription reactions. In these reactions, PFDAA was able to phosphorylate the β-subunit of RNA polymerase II and to induce transcriptase activity, but not DNA replication. The divalent cation requirement for this reaction may be due to the formation of a ternary complex with the template strand and ATP.

Chemische Eigenschaften

• Molekulargewicht: 443.18 g/mol
• Formel: C₁₀H₁₂FN₅O₁₀P₂
• Reinheit: Min. 95%