Produktinformation
- 3-Pyridinecarboxylic acid, 4-amino-2-chloro-
- 2-Chloro-4-aminonicotinic acid
- 4-Amino-2-chloro-3-pyridinecarboxylic acid
4-Amino-2-chloronicotinic acid is a nitrogenous organic compound. It is a synthetic molecule that can be used as a substrate for the chemical reactions of pyrimidine compounds, such as nucleosides and nucleotides, and it has been used as a lead structure in the design of drugs that inhibit tyrosine kinase. The synthesis of this compound involves the reaction of 4-aminoquinoline with chloroacetic acid. This synthetic process has been optimized to produce high yields and purity levels. The calcium-sensing receptor (CaSR) is an important regulator of parathyroid function, which in turn regulates calcium homeostasis in the body. A number of heterocycles have been synthesized and tested as CaSR inhibitors, with 4-amino-2-chloronicotinic acid being one of them. In vitro studies have shown that this compound inhibits CaSR activity at picomolar concentrations.
Chemische Eigenschaften
Technische Anfrage zu: 3D-TQB67838 4-amino-2-chloronicotinic acid
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