Desmethyl dabrafenib

CAS: 1195765-47-9

Ref. 3D-VXB76547

Produktinformation

• Name: Desmethyl dabrafenib
• Synonyme: Benzenesulfonamide, N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1-methylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-, N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(1-methylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide

Beschreibung

Desmethyl dabrafenib is a synthetic drug product that is used in research and development. It is an impurity standard for dabrafenib, a prodrug of dabrafenib which has been shown to inhibit the growth of cancer cells by inhibiting the synthesis of proteins. Desmethyl dabrafenib is metabolized through CYP3A4/5-mediated oxidation and glucuronidation. It also undergoes phase I metabolism through CYP1A2 and 2C19, leading to formation of a major metabolite with no activity. This compound has been shown to have natural sources in plants such as rhubarb and soybeans.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 505.50 g/mol
• Formel: C₂₂H₁₈F₃N₅O₂S₂
• Reinheit: Min. 95%