Produktinformation
- Anthraquinone, 1,2,3,4-tetrahydro-1β,2β,3β,5,8-pentahydroxy-6-methoxy-3-methyl-
- 1,4-Anthracenedione, 5,6,7,8-tetrahydro-5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-, [5S-(5α,6β,7β)]-
- (5S,6R,7S)-5,6,7,8-Tetrahydro-5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-1,4-anthracenedione
- 1,4-Anthracenedione, 5,6,7,8-tetrahydro-5,6,7,9,10-pentahydroxy-2-methoxy-7-methyl-, (5S,6R,7S)-
Bostrycin is a natural product that is isolated from the plant Bostrychia crenata. It has been shown to be effective against bacterial strains such as Staphylococcus epidermidis, Escherichia coli, and Salmonella enterica. Bostrycin inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Bostrycin also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture
Chemische Eigenschaften
Technische Anfrage zu: 3D-WAA87981 Bostrycin
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