GSK343
CAS: 1346704-33-3
Ref. 3D-WDC70433
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Produktinformation
- 1-(1-Methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
- 1H-Indazole-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-
- Gsk 343
- N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
GSK343 is a compound that inhibits the activity of histone methyltransferases. It is used in the treatment of cancer and has been shown to inhibit the growth of Hl-60 cells and 3T3-L1 preadipocytes. GSK343 also inhibits the proliferation of epithelial mesenchymal cells, which may be due to its ability to induce cell cycle arrest at G2/M phase. The inhibition of cancer cell proliferation by GSK343 has been linked to increased levels of the protein p27, which binds to cyclin D and prevents its association with CDK4 or CDK6. This results in reduced levels of cyclin E, Rb phosphorylation, and subsequent release from Rb inhibition. This leads to an increase in S phase followed by apoptosis. In addition, GSK343 has been shown to inhibit polymerase chain reaction (PCR) amplification of DNA by binding to double stranded DNA.
Chemische Eigenschaften
Technische Anfrage zu: 3D-WDC70433 GSK343
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