3-Sulfonyl-pyrazolo(1,5-A)pyrimidine

CAS: 1173103-84-8

Ref. 3D-YWB10384

Produktinformation

• Name: 3-Sulfonyl-pyrazolo(1,5-A)pyrimidine
• Synonyme: 3-Benzenesulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine, 5,7-Dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine, Pyrazolo[1,5-a]pyrimidine, 5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)-, AVN 211

Beschreibung

3-Sulfonyl-pyrazolo(1,5-A)pyrimidine is a potent inhibitor of ion channels that are selective for potassium and calcium. It is a potential drug candidate for the treatment of epilepsy and other diseases. 3-Sulfonyl-pyrazolo(1,5-A)pyrimidine binds to the extracellular domain of the potassium channel Kv1.2 with high affinity (Ki = 0.3 nM). This binding blocks the channel pore and prevents the passage of ions through it. The inhibition is reversible, which means that 3-sulfonyl-pyrazolo(1,5-A)pyrimidine can be removed from the channel by adding external potassium ions or calcium ions. This compound also inhibits voltage gated calcium channels in a similar manner as it does for potassium channels.

• Marke: Biosynth

Chemische Eigenschaften

• Molekulargewicht: 333.4 g/mol
• Formel: C₁₅H₁₅N₃O₂S₂
• Reinheit: Min. 95%