Bufotalin

CAS: 471-95-4

Ref. BP-BP0290

Produktinformation

• Name: Bufotalin
• Synonyme: Bufotaline, (3Beta,5Beta,8Xi,9Xi,16Beta)-16-(Acetyloxy)-3,14-Dihydroxybufa-20,22-Dienolide, (3β,5β,16β)-16-(Acetyloxy)-3,14-dihydroxybufa-20,22-dienolide, 16-(Acetyloxy)-3,14-Dihydroxybufa-20,22-Dienolide, 3b,14,16b-Trihydroxy-5b-bufa-20,22-dienolide 16-acetate, 5β-Bufa-20,22-dienolide, 3β,14,16β-trihydroxy-, 16-acetate, Bufa-20,22-dienolide, 16-(acetyloxy)-3,14-dihydroxy-, (3β,5β,16β)-, NSC 89596

Beschreibung

Bufotalin is a cardiotoxic bufanolide steroid, cardiac glycoside analogue. Bufotalin has anti-cancer activity, it can induce apoptosis in Hep 3B cells, and caspase-8 inhibitor (Z-IETD) or wide-ranging caspase inhibitor (Z-VAD) significantly suppresses the bufotalin-induced apoptosis. Bufotalin is a powerful sensitizer of death receptor-induced apoptosis in cancer cells, it promotes death receptor-mediated cell death, especially TRAIL-induced apoptosis, through activation of caspase-3 and PARP-1.

• Marke: Biopurify

Chemische Eigenschaften

• Molekulargewicht: 444.568
• Formel: C₂₆H₃₆O₆
• Reinheit: 95%~99%